GLP-1 Weight Loss
Tirzepatide
A dual-agonist GLP-1 / GIP program designed for patients seeking advanced metabolic results under provider direction with flat-rate pricing.
Available by consultation
003 — Tirzepatide medical protocol mapping placeholder.
Clinical Overview
How Tirzepatide works
The first medication in its class to engage two metabolic pathways simultaneously — and the reason its trial outcomes set a new ceiling.
Engages the GIP receptor
Targets glucose-dependent insulinotropic polypeptide — a metabolic pathway most weight-management medications do not address.
Engages the GLP-1 receptor
Simultaneously mimics GLP-1 — suppressing appetite and slowing how quickly food leaves the stomach.
Combined metabolic effect
The dual mechanism produces the highest average weight loss recorded in any GLP-1-class clinical trial to date.
Candidacy Profiling
A considered fit, not a funnel.
Adults seeking the most advanced GLP-1-class protocol, with the supervision and titration discipline that this medication requires.
- Adults 18+ with a BMI of 27 or higher, or 25+ with weight-related conditions
- Patients who have plateaued on a single-agonist GLP-1 and want to escalate under supervision
- Members for whom faster onset and higher trial averages are clinically appropriate
- Personal or family history of medullary thyroid carcinoma or MEN 2
- Pregnancy, breastfeeding, or planning pregnancy
- Active pancreatitis or untreated severe gastrointestinal disease
Expected Timeline
What to Expect
Tirzepatide tends to act faster and reach further than single-agonist GLP-1s. Your provider titrates carefully to the dose that fits your body.
- 01
Month 1
Titration
Faster initial response than single-agonist GLP-1s. Careful dose escalation begins.
- 02
Month 3
Established
Therapeutic dose reached. Strong metabolic momentum; appetite consistently reduced.
- 03
Month 6
~20%
Average body weight reduction in published trials. Many members exceed this range.
- 04
Year 1+
Sustained
Sustained reduction for the majority of members who remain in the program.
Outcomes referenced from SURMOUNT-1 trial data. Individual results depend on starting weight, dose, and adherence.
Your Concierge Support
A licensed clinician, matched to you.
At CareNexus, every patient is reviewed, diagnosed, and cared for by Pan Li, PA-C, DMSc/Psych. You see the same dedicated clinician every single visit, ensuring true continuity of care. No rotating callcenter doctors, no explaining your story over and over. Your primary care, psychiatry, and weight management are fully synchronized. Direct messaging and telehealth access on your schedule.
- 01Compounded medication
- Prepared by partner compounding pharmacies and shipped on a structured cadence.
- 02Dedicated provider
- Every interaction is coordinated directly by Pan Li, PA-C, DMSc/Psych — not a rotating callcenter.
- 03Provider-directed dosing
- Titration and adjustments at every transition under expert clinical supervision.
- 04Direct message access
- Reach your provider directly between scheduled check-ins via your secure patient portal.
- 05Structured check-ins
- Cadenced reviews to keep your protocol and overall care plan calibrated to your response.
- 06Discreet direct delivery
- Temperature-controlled, unmarked packaging delivered direct to your door.
The CareNexus Standard
A standard of care built around your whole story, physical and mental.
- 01.One Provider, Every Need
- Stop juggling four different doctors who don't talk to each other. Your primary care, urgent care, psychiatry, psychotherapy, and weight management are all coordinated by Pan Li, PA-C, DMSc/Psych.
- 02.Smarter, Direct Access
- Direct Primary Care eliminates the insurance circus. No prior authorizations, no denied claims, and no surprise bills. You get same-week appointments and direct access to your provider.
- 03.Personalized & Coordinated
- When one dedicated provider manages your physical and mental health, nothing falls through the cracks. Your prescriptions, therapeutic plans, and labs are fully integrated.
Clinical Safety
No medication is right for everyone.
Common side effects
Most common during titration: nausea, decreased appetite, and digestive changes. Typically mild and resolve as the body adjusts to each step in the protocol.
Clinical Contraindications
Not appropriate for patients with a personal or family history of medullary thyroid carcinoma or MEN 2, or for patients who are pregnant or breastfeeding. Full medical history is reviewed before any prescription is authorized.
CareNexus Clinic protocols are prepared by partner compounding pharmacies in the United States. Compounding pharmacies are regulated by both state boards and the FDA and have been part of American medicine since long before mass-manufactured drugs existed. The active ingredient is prepared per your protocol — supervised by your provider — and delivered direct to your door.
Clinical Experience
From members of the Tirzepatide program.
- “
I had done six months on Semaglutide and plateaued. The switch to Tirzepatide was a second wind. I am down another twenty-two pounds in four months and feel like myself again.
- “
Honestly the speed surprised me. By week three I had to start setting reminders to eat — that had never been my problem. My energy is up and my labs are better than they have been in a decade.
- “
I was skeptical that the higher cost was worth it. After comparing my own progress to friends on Semaglutide, the answer for me was yes. The provider helped me think it through honestly.
Frequently Asked
Questions worth asking before you begin.
Every program begins with an online consultation. If your provider authorizes treatment, your protocol is prepared by a partner compounding pharmacy and delivered direct to your door, with structured check-ins and direct messaging access to your provider throughout.
We believe in complete transparency. Our programs feature flat-rate pricing with zero hidden fees, zero consultation charges, and no dose-change surcharges. The price we quote is the price you pay, period.
CareNexus Clinic operates via telehealth across CA, IL, MI, NY, UT, VA, and WI.
Pan Li, PA-C, DMSc/Psych reviews your consultation and authorizes treatment where medically appropriate. You see the same dedicated clinician every single visit, ensuring true continuity of care.
Memberships may be canceled with 30 days' notice prior to the next billing cycle. Consultations, medical visits, and fulfilled prescriptions are non-refundable once services begin or medication is processed.
Yes. CareNexus Clinic is HIPAA compliant. Your medical information is shared only with your assigned provider and the dispensing pharmacy. We never sell or share your data.
Comparison Protocol
Semaglutide
The foundational single-agonist GLP-1 program. Lower trial averages, often the right starting point.
Begin Consultation
The Tirzepatide program begins with a conversation.
Your consultation is reviewed by your dedicated provider. If authorized, your protocol is prepared by a partner compounding pharmacy and delivered direct to your door.